Title |
Endothelial- and Immune Cell-Derived Extracellular Vesicles in the Regulation of Cardiovascular Health and Disease
|
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Published in |
JACC: Basic to Translational Science, December 2017
|
DOI | 10.1016/j.jacbts.2017.08.004 |
Pubmed ID | |
Authors |
Felix Jansen, Qian Li, Alexander Pfeifer, Nikos Werner |
Abstract |
Intercellular signaling by extracellular vesicles (EVs) is a route of cell-cell crosstalk that allows cells to deliver biological messages to specific recipient cells. EVs convey these messages through their distinct cargoes consisting of cytokines, proteins, nucleic acids, and lipids, which they transport from the donor cell to the recipient cell. In cardiovascular disease (CVD), endothelial- and immune cell-derived EVs are emerging as key players in different stages of disease development. EVs can contribute to atherosclerosis development and progression by promoting endothelial dysfunction, intravascular calcification, unstable plaque progression, and thrombus formation after rupture. In contrast, an increasing body of evidence highlights the beneficial effects of certain EVs on vascular function and endothelial regeneration. However, the effects of EVs in CVD are extremely complex and depend on the cellular origin, the functional state of the releasing cells, the biological content, and the diverse recipient cells. This paper summarizes recent progress in our understanding of EV signaling in cardiovascular health and disease and its emerging potential as a therapeutic agent. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 15% |
Germany | 3 | 15% |
United States | 3 | 15% |
Mexico | 2 | 10% |
Switzerland | 1 | 5% |
Portugal | 1 | 5% |
Canada | 1 | 5% |
Netherlands | 1 | 5% |
Nigeria | 1 | 5% |
Other | 0 | 0% |
Unknown | 4 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 9 | 45% |
Members of the public | 8 | 40% |
Practitioners (doctors, other healthcare professionals) | 2 | 10% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 131 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 21% |
Student > Doctoral Student | 15 | 11% |
Researcher | 14 | 11% |
Student > Master | 11 | 8% |
Student > Bachelor | 9 | 7% |
Other | 21 | 16% |
Unknown | 33 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 20% |
Biochemistry, Genetics and Molecular Biology | 24 | 18% |
Agricultural and Biological Sciences | 10 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
Engineering | 5 | 4% |
Other | 17 | 13% |
Unknown | 42 | 32% |