Title |
CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload
|
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Published in |
JACC: Basic to Translational Science, March 2018
|
DOI | 10.1016/j.jacbts.2017.12.006 |
Pubmed ID | |
Authors |
Bindiya Patel, Shyam S. Bansal, Mohamed Ameen Ismahil, Tariq Hamid, Gregg Rokosh, Matthias Mack, Sumanth D. Prabhu |
Abstract |
Although chronic inflammation is a central feature of heart failure (HF), the immune cell profiles differ with different underlying causes. This suggests that for immunomodulatory therapy in HF to be successful, it needs to be tailored to the specific etiology. Here, the authors demonstrate that monocyte-derived C-C chemokine receptor 2 (CCR2)+ macrophages infiltrate the heart early during pressure overload in mice, and that blocking this response either pharmacologically or with antibody-mediated CCR2+ monocyte depletion alleviates late pathological left ventricular remodeling and dysfunction, T-cell expansion, and cardiac fibrosis. Hence, suppression of CCR2+ monocytes/macrophages may be an important immunomodulatory therapeutic target to ameliorate pressure-overload HF. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 18% |
United Kingdom | 2 | 9% |
Belgium | 1 | 5% |
Poland | 1 | 5% |
China | 1 | 5% |
Uruguay | 1 | 5% |
Colombia | 1 | 5% |
Venezuela, Bolivarian Republic of | 1 | 5% |
India | 1 | 5% |
Other | 2 | 9% |
Unknown | 7 | 32% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 13 | 59% |
Science communicators (journalists, bloggers, editors) | 4 | 18% |
Scientists | 3 | 14% |
Practitioners (doctors, other healthcare professionals) | 2 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 141 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 28 | 20% |
Student > Ph. D. Student | 26 | 18% |
Student > Bachelor | 16 | 11% |
Student > Doctoral Student | 11 | 8% |
Student > Master | 10 | 7% |
Other | 17 | 12% |
Unknown | 33 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 23% |
Biochemistry, Genetics and Molecular Biology | 30 | 21% |
Agricultural and Biological Sciences | 16 | 11% |
Immunology and Microbiology | 7 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 9 | 6% |
Unknown | 43 | 30% |