Tetelím se při pozorování toho, jak krásně postupuje genetika. Z genů už teď lze odhadnout riziko některých nemocí lépe, než ze stávajících rizikových faktorů
RT @minouye271: Even 4-5 years ago, polygenic scores for coronary artery disease & breast cancer performed the same as or better than any o…
RT @minouye271: Even 4-5 years ago, polygenic scores for coronary artery disease & breast cancer performed the same as or better than any o…
RT @minouye271: Even 4-5 years ago, polygenic scores for coronary artery disease & breast cancer performed the same as or better than any o…
RT @minouye271: Even 4-5 years ago, polygenic scores for coronary artery disease & breast cancer performed the same as or better than any o…
RT @minouye271: Even 4-5 years ago, polygenic scores for coronary artery disease & breast cancer performed the same as or better than any o…
NB accessible links to the CAD and BC studies https://t.co/AZ15omRgcQ https://t.co/4c4eMo6naK
Even 4-5 years ago, polygenic scores for coronary artery disease & breast cancer performed the same as or better than any other single conventional risk factor Looking for other key refs in other diseases where this has been shown https://t.co/E8US9Y
RT @minouye271: Multiple lines of evidence for polygenic score guided treatment intensity for patients on LDL or BP meds: -PGS_SBP & PGS_L…
RT @minouye271: Multiple lines of evidence for polygenic score guided treatment intensity for patients on LDL or BP meds: -PGS_SBP & PGS_L…
Multiple lines of evidence for polygenic score guided treatment intensity for patients on LDL or BP meds: -PGS_SBP & PGS_LDL stratify patients w/inadequately controlled SBP & LDL https://t.co/bgVjiR7h1Y -PGS_CAD stratifies treated patients for fu
RT @pnatarajanmd: Pooling of data from individual PRS generated & validated in diverse cohorts can improve the predictive ability of PRS ac…
RT @pnatarajanmd: Pooling of data from individual PRS generated & validated in diverse cohorts can improve the predictive ability of PRS ac…
Pooling of data from individual PRS generated & validated in diverse cohorts can improve the predictive ability of PRS across diverse populations. This concept was advanced by @GadAbraham1 @minouye271 for CAD (https://t.co/wc18VaahZ3) & stroke (htt
@minouye271 @bvilhjal @privefl @clara_albi In the supplement here: https://t.co/LkXBvIffFy (happy to send via email as well)
RT @minouye271: @jodieingles27 @GadAbraham1 Amazing how many insights were in the 2018 (https://t.co/0XRthYrFtJ) and the 2016 (https://t.co…
@jodieingles27 @GadAbraham1 Amazing how many insights were in the 2018 (https://t.co/0XRthYrFtJ) and the 2016 (https://t.co/hyLaS3RIUe) CAD PRS papers 2016 PRS underpinned Finnish GeneRISK study -> positive behaviour change 2018 PRS helped transform f
RT @jodieingles27: Predictive power of PRS and other risk factors for coronary artery disease. Very nice talk from @GadAbraham1 and paper h…
Predictive power of PRS and other risk factors for coronary artery disease. Very nice talk from @GadAbraham1 and paper here: https://t.co/3e6ec8K2Ib #ICCG2022 #iccg22 #genechat @minouye271 https://t.co/hNXL1sKtLK
Let me be specific https://t.co/3PHdMeq6QM https://t.co/VO79imYyhR
These GWAS scores can be used to identify high risk individuals: you can target preventative measures (here’s a study of polygenic risk being more predictive of developing heart disease than all our standard clinical measures and the combo is best of all)
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: What can health data do? We can prevent (many) thousands more heart attacks, strokes and other diseases in the coming years…
RT @minouye271: What can health data do? We can prevent (many) thousands more heart attacks, strokes and other diseases in the coming years…
RT @minouye271: What can health data do? We can prevent (many) thousands more heart attacks, strokes and other diseases in the coming years…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: What can health data do? We can prevent (many) thousands more heart attacks, strokes and other diseases in the coming years…
What can health data do? We can prevent (many) thousands more heart attacks, strokes and other diseases in the coming years 👇 #datasaveslives
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @CamBakerSGI: The future of cardiovascular disease risk prediction is likely to include polygenic risk scores. The Cambridge Baker partn…
RT @CamBakerSGI: The future of cardiovascular disease risk prediction is likely to include polygenic risk scores. The Cambridge Baker partn…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @CamBakerSGI: The future of cardiovascular disease risk prediction is likely to include polygenic risk scores. The Cambridge Baker partn…
The future of cardiovascular disease risk prediction is likely to include polygenic risk scores. The Cambridge Baker partnership is playing a world leading role in PRS design and translation. We couldn't be prouder of all our research in this area! 🤓🥂 http
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
RT @minouye271: Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab:…
Really good @Nature article summarising PRS research for cardiovascular disease Additional relevant papers from our lab: CAD PRS 2016 https://t.co/hyLaS3RIUe CAD PRS 2018 https://t.co/t1CnxA5Oat Stroke PRS 2019 https://t.co/27Iw8vwTtT PGS Catalog http
RT @minouye271: A shout out to the @PGSCatalog and our upcoming @ClinGenResource PRS Reporting Standards. Let's keep our genomic data FAIR…
A shout out to the @PGSCatalog and our upcoming @ClinGenResource PRS Reporting Standards. Let's keep our genomic data FAIR, transparent and reproducible. #JustSayNo to black box polygenic scores.
RT @minouye271: NB: Our modelling utilised these 2 polygenic scores. Coronary artery disease (PGS000018 https://t.co/u9UEIvYEde) -> citati…
RT @minouye271: NB: Our modelling utilised these 2 polygenic scores. Coronary artery disease (PGS000018 https://t.co/u9UEIvYEde) -> citati…
RT @minouye271: NB: Our modelling utilised these 2 polygenic scores. Coronary artery disease (PGS000018 https://t.co/u9UEIvYEde) -> citati…
NB: Our modelling utilised these 2 polygenic scores. Coronary artery disease (PGS000018 https://t.co/u9UEIvYEde) -> citation https://t.co/t1CnxA5Oat Ischaemic stroke (PGS000039 https://t.co/HdnFTa7aUC) -> citation https://t.co/27Iw8vwTtT
@ShaiCarmi It is amazing how dangerous "genetics" sounds to people. I really don't get why genetic and non-genetic risk factors are treated so differently. If I want to predict disease risk, say for CAD, we know that measurable risk factors still outcompet
RT @minouye271: Cool findings on the underlying pathways likely driven by polygenic risk of CAD -> https://t.co/Jdbphp4Xes The PRS they as…
Cool findings on the underlying pathways likely driven by polygenic risk of CAD -> https://t.co/Jdbphp4Xes The PRS they assess is the CAD metaGRS from https://t.co/TxBWfY52lj
@jotzou Nice work Joanna. The construction of the PRS here is everything and from what I can tell it looks like your PRS is much weaker than previous CAD metaGRS (https://t.co/Dtc1RDoF8X) and Khera et al as well. Incident CAD HR of ~1.60 vs ~1.32. Did you
RT @minouye271: Further reading for this article https://t.co/3tbYPjfZDy Summary https://t.co/NpttQTO5VR Cancer https://t.co/GN4wtYtcAK h…
RT @minouye271: Further reading for this article https://t.co/3tbYPjfZDy Summary https://t.co/NpttQTO5VR Cancer https://t.co/GN4wtYtcAK h…
Further reading for this article https://t.co/3tbYPjfZDy Summary https://t.co/NpttQTO5VR Cancer https://t.co/GN4wtYtcAK https://t.co/4c4eMonY2i Heart disease https://t.co/hyLaS49jLM https://t.co/rS8Eby7bRY Quantitative genetics https://t.co/h7VcvM9DtV
@minouye271 @rainermpg @aidanbutty 3/ To construct our polygenic risk score, we used a metaGRS approach. A metaGRS is a weighted average of several polygenic risk scores; we have used this approach previously for coronary artery disease (CAD) https://t.co/
RT @natar210: Up next at the Cardiovascular Precision Medicine Symposium is @GadAbraham1 taking about Polygenic risk score for coronary art…
RT @natar210: Up next at the Cardiovascular Precision Medicine Symposium is @GadAbraham1 taking about Polygenic risk score for coronary art…
RT @natar210: Up next at the Cardiovascular Precision Medicine Symposium is @GadAbraham1 taking about Polygenic risk score for coronary art…
@OzCvA
Up next at the Cardiovascular Precision Medicine Symposium is @GadAbraham1 taking about Polygenic risk score for coronary artery disease - check out his recent publication in JACC for more details https://t.co/2FWwdp5EXf @BakerResearchAu @CamBakerSGI https
@GadAbraham1 @uk_biobank #APRS19 GA: metaGRS selects 12 PRS as most predictive. HR of 3 in top 1% for stroke. More predictive than previous GRS. metaGRS in CAD explained here: https://t.co/N4uf8Gdzi0
RT @SteinbergJulia: MI: metaGRS ("score of scores") gives prediction boost. In UK Biobank, see some effect heterogeneity in diverse populat…
RT @cathrynlewis: @minouye271 #APRS19 MI: metaGRS for CAD in 482k @uk_biobank .New metaGRS score https://t.co/dCgO8Wedb3. 15 year differe…
RT @SteinbergJulia: MI: metaGRS ("score of scores") gives prediction boost. In UK Biobank, see some effect heterogeneity in diverse populat…
MI: metaGRS ("score of scores") gives prediction boost. In UK Biobank, see some effect heterogeneity in diverse populations. https://t.co/PkhCL5IpKm Score has been independently validated by other studies, too. #APRS19
@minouye271 #APRS19 MI: metaGRS for CAD in 482k @uk_biobank .New metaGRS score https://t.co/dCgO8Wedb3. 15 year differences in mean age of CAD from top/bottom quintiles of risk in men. MetaGRS shows heterogeneity in diverse populations – partly GWAS stu
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
RT @metapredict: Yikes! “Although the AUC in the full model is high in both ancestries (0.57-0.84), showing ability to distinguish between…
Yikes! “Although the AUC in the full model is high in both ancestries (0.57-0.84), showing ability to distinguish between cases and controls” T2DM AUC was <0.6 AUC. Do they know ~0.5 is random I wonder... big cohort, small p-values but translatable?
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
"the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome-wide PRS in a new biobank, independent of our or @minouye271 original reports https://t.co/bEoCfzcnRg https://t.co/bydETs45ZP
@emilyswlau @JACCJournals @JenHoCardiology @goosecoid @MGHHeartHealth Interestingly no sex interaction with polygenic risk (CAD). Though baseline hazard clearly different. https://t.co/Dtc1RD74hp
RT @minouye271: Thanks @fiosgenomics. The underlying research on polygenic risk of CAD/CVD is here: 2016: 49k GRS https://t.co/hyLaS3RIUe…
Thanks @fiosgenomics. The underlying research on polygenic risk of CAD/CVD is here: 2016: 49k GRS https://t.co/hyLaS3RIUe 2018: metaGRS https://t.co/Dtc1RD74hp 2018: GeneRisk https://t.co/DZj20ORZgJ 2019: Public health modeling https://t.co/iA7PXAPY9u
Interesting thread
RT @bvilhjal: @cecilejanssens @shing_wan @MarigortaLab I really like the work by @minouye271 @GadAbraham1 and colleagues. I would argue…
@cecilejanssens @shing_wan @MarigortaLab I really like the work by @minouye271 @GadAbraham1 and colleagues. I would argue that https://t.co/CQjudgqElB checks most of those boxes.
@jpirruccello @hmkyale @JACCJournals @ACCinTouch @medrxivpreprint @jsross119 I thought they already accepted preprints... https://t.co/z6zJQnoTUE @biorxiv_genetic https://t.co/rhbyxMjtql @JACCJournals cc @minouye271 @GadAbraham1
BWWAAAHAAHAHAHAHAHAHAHAHAHAHAAHAH!!!!!
@cecilejanssens @MuinJKhoury @uk_biobank @biorxiv_genetic Well we did just discuss this a few months ago..... the rationale, and initial methodology, was here and in its supplement https://t.co/Dtc1RDoF8X
RT @ksamocha: Fischer: Different large-scale GWAS meta-analyses give different polygenic scores. Potential solve is combining scores, e.g.…
RT @ksamocha: Fischer: Different large-scale GWAS meta-analyses give different polygenic scores. Potential solve is combining scores, e.g.…
RT @ksamocha: Fischer: Different large-scale GWAS meta-analyses give different polygenic scores. Potential solve is combining scores, e.g.…