@ChristofferBN @MichaelMindrum https://t.co/Ars7CatvRO

@theproof @john_e_bones @Lipoprotein Link to the paper I think they were referencing - https://t.co/EjEQO2csxX. Frequency of cardiac events low & dose effect of pcsk9 alleles mild. Despite this it showed reduced cv mortality. to be powered for all cau

@FoolproofMaster @ChristofferBN @Tom_Babington1 @ScepticalDoctor I think it is this one here: https://t.co/EjEQO2csxX

@theproof @realDaveFeldman @Lipoprotein and here is the paper I think that was being referenced: https://t.co/EjEQO2csxX

@holmanm @DesignedNature What about Mendelian Radomization studies. Those born with PCSK9 variation, who have LOW LDL for Life. They have decreased ASCVD risk and lower MACE. https://t.co/r35VmLvQxD

@MohammedAlo @PeterJAnderson_ @Drlipid @LowCarbEyeDoc @rcextremebike @TuckerGoodrich @AsarCadyn @SanDiegoJoey @theproof I haven’t seen anything close to that this far — the largest paper I’ve seen for PCSK9 LOF is this one. Again, these do show lower CVD

@SaulNutri @SerHevNav https://t.co/oJsM1I94mo

@Clint_OMeley @LDLSkeptic @MohammedAlo @brownenglisman @DrAseemMalhotra Conclusions: Genetically low LDL cholesterol due to PCSK9 variation was causally associated with low risk of cardiovascular mortality, but not with low all-cause mortality in the gener

@MyNutritionSci @Clint_OMeley @MohammedAlo @NutritionMadeS3 @IMWHorvitz https://t.co/dc58quPLRH this study? “Genetically low LDL cholesterol due to PCSK9 variation was causally associated with low risk of cardiovascular mortality, but not with low all-caus

@LowCarbEyeDoc @TheCarnivoreKid https://t.co/ApRLjKbk9m

@theproof Not MR, but in this https://t.co/tO4Xlyf9DA (based on two prospective cohorts) it was found that "(...) low LDL cholesterol due to PCSK9 variation was causally associated with low risk of cardiovascular mortality, but not with low all-cause mort

@NutritionMadeS3 "Genetically low LDL cholesterol due to PCSK9 variation was causally associated with low risk of cardiovascular mortality, but not with low all-cause mortality in the general population." https://t.co/lWbTfRvnuR

@Tom_Babington1 @PeterFaberSP @JoeSmit73584760 @NutritionMadeS3 On Postmus, I think you’re referring to https://t.co/5NFR4qTEn5 . (Note it uses a generated risk scoring system) This one from Benn looks PCSK9 LOF and shows reduced CV mortality, but not red

@m1cha3lo0o This mechanistic speculation is best investigated using actual LDL-lowering interventions. When investigated, the opposite is found. Higher LDL results in higher all-cause mortality. https://t.co/BtfkKmNmMJ Same is true of MR when there is en

@miseenplace86 @ThreedeeMania @PeterFaberSP ... Yet I haven't seen anything demonstrating this specifically with PCSK9 LOF. In fact, even at large scale there appears to be no difference in ACM. https://t.co/8PGZL5gj4k Look up abetalipoproteinemia and hyp

@StolteThiago @AlexJLeaf @jerryteixeira @raphaels7 @DoctorTro @IMWHorvitz Here is one that tracks all-cause mortality with the magnitude of LDL-lowering from statin and PCSK9-inhibitor RCTs. https://t.co/bsYM8ROzXm https://t.co/zttqAbNEa0

RT @The_Nutrivore: @_longevitycoach @POhukainen @DrAseemMalhotra Yeah. The meta-analysis above, and a comprehensive meta-regression analysi…

RT @The_Nutrivore: Looks pretty causal to me. https://t.co/HoKAAqWK7c https://t.co/vFG5GdwNBI https://t.co/kVVyEaygpl https://t.co/DSyGEDd…

RT @The_Nutrivore: Looks pretty causal to me. https://t.co/HoKAAqWK7c https://t.co/vFG5GdwNBI https://t.co/kVVyEaygpl https://t.co/DSyGEDd…

RT @The_Nutrivore: Looks pretty causal to me. https://t.co/HoKAAqWK7c https://t.co/vFG5GdwNBI https://t.co/kVVyEaygpl https://t.co/DSyGEDd…

RT @The_Nutrivore: @Adityalch @MattMadore576 @shameermulji @Tom_Babington1 Correction, without evidence that @Adityalch was willing to read…

@Adityalch @MattMadore576 @shameermulji @Tom_Babington1 Correction, without evidence that @Adityalch was willing to read and understand. 🤡 https://t.co/HTrUnar4gQ

Looks pretty causal to me. https://t.co/HoKAAqWK7c https://t.co/vFG5GdwNBI https://t.co/kVVyEaygpl https://t.co/DSyGEDdGhE ¯\_(ツ)_/¯ https://t.co/9dvYa93CRB

RT @The_Nutrivore: The effect of statins in isolation is also clear, despite the obvious heterogeneity between individual trials. This is w…

The effect of statins in isolation is also clear, despite the obvious heterogeneity between individual trials. This is why we have meta-analysis and meta-regression. PCSK9-inhibitors are borderline. It's safe to assume this is a power issue at this point.

@Jevan @POhukainen Meta-regression showing reduction in ACM with statins in primary prevention (Figure 5). https://t.co/ImtbtkgkAv Also, multiple MRs: https://t.co/ne2Emg0zNP https://t.co/tP3Kpz3Bvj

@IdanOnTweeter @DrPaulMason Not sure what it means. But it certainly doesn't negate the fact that lipid-lowering therapy lowers CVD mortality and all-cause mortality. lol https://t.co/tmrCeaCjhH https://t.co/927kMw1N3h https://t.co/fekqoYfG7j 🤷‍♂️

RT @The_Nutrivore: @_longevitycoach @POhukainen @DrAseemMalhotra Yeah. The meta-analysis above, and a comprehensive meta-regression analysi…

RT @dylanarmbruste3: Domanski et al 2020 https://t.co/2CI8fotjfo Benn et al 2019 https://t.co/BbS6952AkF (2/n) https://t.co/0M7mrGTcZ1

Domanski et al 2020 https://t.co/2CI8fotjfo Benn et al 2019 https://t.co/BbS6952AkF (2/n) https://t.co/0M7mrGTcZ1

@pauljmey I'd suggest analysing meta-regressions which test the relationship between LDL-lowering and all-cause mortality. https://t.co/gulbq5u4jJ https://t.co/vS1hfkMf42

Even those with PCSK9 variants (a strong genetic LDL-C reducer) did not have a greater number of events. https://t.co/m3jI91wDEf

@AxiomNutrifit @CaloriesProper That's because cancer lowers LDL, not because low LDL causes cancer https://t.co/gShFZtCddl https://t.co/Cp6kdbJxSS https://t.co/9TGiC0F9TO https://t.co/UuaGKTfqLq

@IdanOnTweeter https://t.co/xTcHebU8nv

@Herd851 @JamesClark39737 @DrAseemMalhotra @BMJ_EBM @ProfTimNoakes @LDLSkeptic @FatEmperor @DrPascalMeier @drjasonfung @lowcarbGP @FructoseNo @SBakerMD @drmarkhyman @zoeharcombe Explain how. Here's the paper. Explain in detail, study by study, how the conc

@_longevitycoach @EricaHauver @BMJ_EBM @DrAseemMalhotra But honestly, neither of our analyses are proper meta-regression analyses. When analyzed using a meta-regression, it is revealed that there is an additional benefit of hitting the LDL target, and redu

@_longevitycoach @POhukainen @DrAseemMalhotra Yeah. The meta-analysis above, and a comprehensive meta-regression analysis linked below. Statin use shows a dose dependant decrease to ACM that is statistically significant. https://t.co/Fiqyb9dqmS

RT @The_Nutrivore: It's a completely inappropriate analysis method to use. When there is an obvious moderator variable (like LDL), a meta-r…

@psychfarm @POhukainen The truth is. My meta-analysis is a poor method for investigating this question. Aseem's methods are atrocious for investigating this question. https://t.co/vFG5GdOp0i https://t.co/kVVyEagFxN What we really need is a meta-regressi

@JamesClark39737 @DrAseemMalhotra @BMJ_EBM @ProfTimNoakes @LDLSkeptic @FatEmperor @DrPascalMeier @drjasonfung @lowcarbGP @FructoseNo @SBakerMD @drmarkhyman @zoeharcombe Screw my meta-analysis, he's going to have to explain these results of this meta-regres

@FoodFirst_Ty This isn't even the best way to analyze the available data. https://t.co/Fiqyb9v1Ls

RT @The_Nutrivore: It's a completely inappropriate analysis method to use. When there is an obvious moderator variable (like LDL), a meta-r…

It's a completely inappropriate analysis method to use. When there is an obvious moderator variable (like LDL), a meta-regression is the best tool. Meta-regression analyses of statins show a benefit to heart disease mortality and all-cause mortality. 🤷‍♂️

@chelseakwt Of course. There is a dose-response reduction in risk with the lowering of LDL-C (specifically apoB) in statin trials: https://t.co/VtxFdIpK79 We also have MR's showing SNP's that reduce LDL have a dose-response to survival: DOI: 10.1093/ije/d

RT @DiscoStew66: So the point of PCSK9 inhibitors is what exactly? 🤔 “Genetically low LDL cholesterol due to PCSK9 variation was causally…

RT @DiscoStew66: So the point of PCSK9 inhibitors is what exactly? 🤔 “Genetically low LDL cholesterol due to PCSK9 variation was causally…

So the point of PCSK9 inhibitors is what exactly? 🤔 “Genetically low LDL cholesterol due to PCSK9 variation was causally associated with low risk of cardiovascular mortality, but not with low all-cause mortality in the general population.” https://t.co/U

@Tom_Babington1 https://t.co/mibnxyKEu0

@brive1987 @babington_tom @FoodFirst_Ty @DaleWil39870290 @KenDBerryMD Are we positing things without justifying them? okay https://t.co/HQvd8g8IPp https://t.co/j7OUZsdgmf https://t.co/f0RshP5lgq

@drmatthewnagra Ironically, that meta-regression of RCTs figure comes from the Mendelian randomization that Ketos love to site showing non stat sig findings for ACM. https://t.co/Fq4Zhrcn77

@PaulSpottswood @LDLSkeptic @DrAseemMalhotra @DrPaulMason @JeffryGerberMD @bschermd @zoeharcombe @lowcarbGP (2/2) "Note that all cause mortality increases with lower LDL levels from cancer/serious infections" no: https://t.co/HQvd8g8IPp https://t.co/YMdk5x

@AviBittMD @DaveKeto @xKloc @AlexJLeaf https://t.co/hJ1CqUGNtu This is the paper they mention specifically I believe.

@AviBittMD @The_Nutrivore @xKloc @AlexJLeaf https://t.co/Yc5XEVytCx

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @DaveKeto: @neeche41 @slithrael @NNeanderMedical @Kitt_S_N_Koola @MarkGiangreco2 @FatEmperor @CliveBeaufoy @gtfinchy @LDLSkeptic @Meursa…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @DaveKeto: @neeche41 @slithrael @NNeanderMedical @Kitt_S_N_Koola @MarkGiangreco2 @FatEmperor @CliveBeaufoy @gtfinchy @LDLSkeptic @Meursa…

@neeche41 @slithrael @NNeanderMedical @Kitt_S_N_Koola @MarkGiangreco2 @FatEmperor @CliveBeaufoy @gtfinchy @LDLSkeptic @MeursaultArthur @holmanm @siobhan_huggins If the drop in LDL were without downside, then those with PCSK9 mutation could cut out CVD rele

@The_Nutrivore @IanCramer @ZKForTre @GardnerPhD Actually, PCSK9 LOF is an excellent example. Lower CVD, yet no reduction in all cause mortality. https://t.co/xpWEDO1bbW

@kevinnbass @maximumcharacte This was the study I was referring to, but it’s been a little while since I read it. https://t.co/QJbaJ8qd4R

@CliffordSosin https://t.co/Yc5XEVytCx

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

@bschermd I found this one the most interesting: Note divergent effect on CVD vs all-cause mortality especially event rate: https://t.co/PB2AbxnUav https://t.co/MMMOm59YFj https://t.co/pl7dm0m8zm

@PsuedoEpiphany @DietDoctor1 Possibly since that was the case with PCSK9 gene variants: https://t.co/PB2Abx6jiX https://t.co/MMMOm5rA3T https://t.co/369OAkGax6

@Plantbiased @EBryceLee @Drlipid "During a median follow-up of 10 years (range 0 to 42 years) and 1,247,225 person-years, there were 3,828 cardiovascular deaths and 16,373 deaths from any cause. " https://t.co/MMMOm5rA3T

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

Genetically low LDL due to loss of function variants in PCSK9 results in lower CVD risk. @JACCJournals https://t.co/mF7NgqcwQ6

RT @cardioprevanz: https://t.co/hrEr8kh6gk @ernestocardio @drjarayg @mencardio @SIAC_cardio @DrPontecarlosi @gonzaeperez @vic_pallares @tor…

RT @cardioprevanz: https://t.co/hrEr8kh6gk @ernestocardio @drjarayg @mencardio @SIAC_cardio @DrPontecarlosi @gonzaeperez @vic_pallares @tor…

https://t.co/hrEr8kh6gk @ernestocardio @drjarayg @mencardio @SIAC_cardio @DrPontecarlosi @gonzaeperez @vic_pallares @torresviera @CardiologiahoyC @jstragazue @recetario1 @fvcpreventiva @mancebin @SVCardiologia @

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

HT: @LDLSkeptic #cholesterol #health #mortality

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @DaveKeto: called it https://t.co/xpWEDO1bbW

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @DaveKeto: called it https://t.co/xpWEDO1bbW

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @DaveKeto: called it https://t.co/xpWEDO1bbW

RT @DaveKeto: called it https://t.co/xpWEDO1bbW

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @bschermd: Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years d…

RT @DaveKeto: called it https://t.co/xpWEDO1bbW

called it

Low LDL from genetically reduced PCSK9 function lowers CV mortality but not all cause mortality. Over 1million person years data so it should be adequately powered. Maybe we need to LDL for something else?@DaveKeto https://t.co/fyj68gE80X