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American College of Cardiology

Article Metrics

Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal

Overview of attention for article published in JACC: Basic to Translational Science, April 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 196)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
37 news outlets
twitter
3 tweeters

Citations

dimensions_citation
1 Dimensions

Readers on

mendeley
2 Mendeley
Title
Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal
Published in
JACC: Basic to Translational Science, April 2018
DOI 10.1016/j.jacbts.2017.12.004
Pubmed ID
Authors

Dimosthenis Giamouridis, Mei Hua Gao, N. Chin Lai, Zhen Tan, Young Chul Kim, Tracy Guo, Atsushi Miyanohara, W. Matthijs Blankesteijn, Erik Biessen, H. Kirk Hammond

Abstract

UCn2 and UCn3 peptides have recently been infused to treat patients with heart failure (HF) but are limited by their short half-lives. A 1-time intravenous injection of virus vectors encoding UCn2 or UCn3 provided sustained increases in plasma concentrations of the peptides. This was associated with increases in both systolic and diastolic left ventricular (LV) function, mediated by increased LV SERCA2a expression and Ca2+ handling. UCn2, but not UCn3, gene transfer reduced fasting glucose and increased glucose disposal. These findings support UCn2 and UCn3 gene transfer as potential treatments for HF and indicate that UCn2 may be an optimal selection in patients with diabetes and HF.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 50%
Student > Ph. D. Student 1 50%
Readers by discipline Count As %
Business, Management and Accounting 1 50%
Agricultural and Biological Sciences 1 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 298. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2018.
All research outputs
#32,480
of 12,077,989 outputs
Outputs from JACC: Basic to Translational Science
#2
of 196 outputs
Outputs of similar age
#1,878
of 257,531 outputs
Outputs of similar age from JACC: Basic to Translational Science
#1
of 14 outputs
Altmetric has tracked 12,077,989 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 196 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,531 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.